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KMID : 0624620140470090524
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BMB Reports
2014 Volume.47 No. 9 p.524 ~ p.529
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Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells
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Hwang Yu-Jin
Song Jae-Whan
Kim Haeng-Ran
Hwang Kyung-A
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Abstract
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Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies have shown that many natural dietary compounds regulate NF-κB and Nrf2, preventing inflammation and oxidative stress. Here, we report major compounds of Prunella vulgaris var. lilacina such as rosmarinic acid, oleanolic acid, ursolic acid and caffeic acid as a potential therapeutic for oxidative stress and inflammation. The major compounds exhibited high anti-inflammatory activity, inhibiting NO, PGE2 production, NF-κB expression and activating Nrf2 expression. In addition, we examined the effect of major compounds on MafK expression. Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation. These findings suggest that oleanolic acid as NF-κB inhibitors can potentially be used in therapeutic applications for the treatment of oxidative stressnduced diseases.
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KEYWORD
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MafK, NF-κB, Nrf2, Oleanolic acid, p65 acetylation
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